A SIMPLE KEY FOR PKRRATING UNVEILED

The activated enzyme then phosphorylates its major substrate, the translational initiation component eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to unique stimuli12, triggering the built-in st